Is approximately 25 kilometers away from Ang Thong city. Though it was originally a small Tambon reporting to Amphoe Wiset Chai Chan, it was promoted as sub-district and then as district in 1965. For its historical importance, Samko is mentioned in the royal chronicle that the Burmese marched their army from Dan Chedi Sam Ong to encamp in Samko before attacking Ayutthaya City. It is also the place where King Naresuan the Great and Phra Ekathotsarot led the troops to Tambon Traphangtru in Suphan Buri province and defeated the enemy by combat on elephant back.
At present, Samko is well known in its native tradition and folk arts. There are some agriculture areas in Samko converted from rice fields to other agriculture land e.g. lotus field, good species coconut plantations estate, and mixed orchard. Farmers know how to develop their career using new technologies to improve agriculture products in both quality and quantity and to earn satisfactory income. Samko is also a land of native songs where both male and female singers take significant roles in conserving and bringing native recreation and songs back to life.